Celleration^® is dedicated to providing health care professionals the scientific evidence they need to provide their patients the highest quality wound care. MIST Therapy® stands apart in the wound care arena due to the extensive clinical data that supports its use to painlessly, accelerate wound healing.

To learn more about the clinical data supporting the use of MIST Therapy^®, review the content below.

To request a copy of the articles below please contact Customer Service @ 866-307-6478.

MIST Therapy® Bibliography

MIST Therapy® Bibliography

Randomized Control Studies.

Ultrasound Therapy for Recalcitrant Diabetic Foot Ulcers: Results of a Randomized, Double-Blind, Controlled Multicenter Study
William J. Ennis, DO; Phil Forman, DPM; Neal Mozen, DPM; Joi Massey, PT; Teresa Conner-Kerr, PhD, PT; Patricio Meneses, PhD; and the MIST Ultrasound Diabetic Foot Study Group
Ostomy Wound Management 2005; 51(8):24-39
Source: Click here to view abstract on PubMed

Treatment of Ischemic Wounds with Noncontact, Low-frequency Ultrasound: The Mayo Clinic Experience, 2004-2006
Steven J. Kavros, DPM, FAPWCA; Jenny L. Miller, PT; and Steven W. Hanna, MPT
Advances in Skin and Wound Care 2007; 20(4): 221-6
Source: Click here to view abstract on PubMed

Prospective Studies

The Impact of Noncontact, Nonthermal, Low-Frequency Ultrasound on Bacterial Counts in Experimental and Chronic Wounds
Thomas Serena, MD FACS; Kwon Lee, MS, FACS, FCCWS; Kan Lam, BS, RLAT; Paul Attar, PhD; Patricio Meneses, PhD, and William Ennis, DO Ostomy Wound Management 2009; 55(1): 22-30
Source: Click here to view abstract on PubMed

Retrospective Studies

Expedited Wound Healing with Noncontact, Low-Frequency Ultrasound Therapy in Chronic Wounds: A Retrospective Analysis
Steven J. Kavros, DPM; David A. Liedl, RN; Andrea J. Boon, MD; Jenny L. Miller, PT; Julie A. Hobbs, PhD; and Karen L. Andrews, MD Adv Skin Wound Care 2008; 21(9):416-23
Source: Click here to view abstract on PubMed

Noncontact Ultrasound Therapy for Adjunctive Treatment of Nonhealing Wounds: Retrospective Analysis
Autumn L Bell, PT, MPT, CLT and Joseph Cavorsi, MD Physical Therapy 2008; 88: 1517-1528
Source: Click here to view abstract on PubMed

A Retrospective Analysis of Acoustic Pressure Wound Therapy: Effects on the Healing Progression of Chronic Wounds
Jaimee Haan, PT, CWS and Sharon Lucich, PT, CWS Journal of the American College of Certified Wound Specialists 2009; 1: 28-34

Adjuvant Use of Acoustic Pressure Wound Therapy for the Treatment of Chronic Wounds
Pamela S. Cole, MSPT, CWS; Jennifer Quisberg, MSPT, CWS and M. Mark Melin, MD, FACS Journal of Wound, Ostomy and Continence Nursing 2009; 36(2):171-177
Source: Click here to view abstract on PubMed

The effect of noncontact, low-intensity, low-frequency therapeutic ultrasound on lower-extremity chronic wound pain: a retrospective chart review.
Gehling ML, Samies JH. Ostomy Wound Management. 2007; 53(3):44-50
Source: Click here to view abstract on PubMed

Observational Studies

Use of Noncontact Low-Frequency Ultrasound in the Treatment of Chronic Foot and Leg Ulcerations: A 51 Patient Analysis
Steven L Kavros, DPM and Erick C. Schenk, MPT
J American Podiatric Medical Association 2007; 97(2):95-101
Source: Click here to view abstract on PubMed

Evaluation of Clinical Effectiveness of MIST Ultrasound Therapy for the Healing of Chronic Wounds.
William J. Ennis, DO; Wesley Valdes, DO; Marianne Gainer, RN; and Patricio Meneses, PhD
Advances in Skin and Wound Care 2006; 19:437-46
Source: Click here to view abstract on PubMed

Ostomy and Wound Management – Sound Evidence Series

Source: www.o-wm.com

Low-Frequency, Noncontact, Nonthermal Ultrasound Therapy: A Review of the Literature
Pamela Unger, PT, CWS
Ostomy Wound Management 2008; 54(1):57-60

Wound Closure and Gradual Involution of an Infantile Hemangioma Using a Noncontact, Low-Frequency Ultrasound Therapy
Thomas Serena, MD, FACS
Ostomy Wound Management 2008; 54(2):68-71

Acoustic Pressure Wound Therapy for Management of Mixed Partial- and Full-Thickness Burns in a Rural Wound Center
John Samies, MD and Marie Gehling, RN, BSN, WOCN
Ostomy Wound Management 2008; 54(3):56-59

Acoustic Pressure Wound Therapy in the Treatment of a Vasculopathy-Associated Digital Ulcer: A Case Study
Christopher Paul Fleming, RN, WCC
Ostomy Wound Management 2008; 54(4):62-65

Combination of Negative Pressure Wound Therapy and Acoustic Pressure Wound Therapy for Treatment of Infected Surgical Wounds: A Case Series
Paul A. Liguori, MD; Kim L. Peters, RN, CWS and Jolene M. Bowers, RN
Ostomy Wound Management 2008; 54(5):50-53

Clinical Effectiveness of Noncontact, Low-Frequency, Nonthermal Ultrasound in Burn Care
Kristin Waldrop, PT, DPT and Ann Serfass, PTA
Ostomy Wound Management 2008; 54(6):66-69

Acoustic Pressure Wound Therapy to Facilitate Granulation Tissue in Sacral Pressure Ulcers in Patients with Compromised Mobility: A Case Series.
Jo Schmuckler, PT
Ostomy Wound Management 2008; 54(8):50-53

Negative Pressure Wound Therapy Combined with Acoustic Pressure Wound Therapy for Infected Post Surgery Wounds: A Case Series
Melanie Howell-Taylor, RN, BSN, CWOCN, DAPWCA; Macy G. Hall, MD, FACS; William J. Brownlee III, MD and Mary Taylor, C-NP
Ostomy Wound Management 2008; 54(9):49–52

Low-frequency, Therapeutic Ultrasound Treatment for Congenital Ectodermal Dysplasia in Toddlers
Debra Caswell, RN, MNS, NP-C and Brianna M. McNulty
Ostomy Wound Management 2008; 54(10):58-61

Acoustic Pressure Wound Therapy in the Treatment of Stage II Pressure Ulcers
Raenell Thomas, RN, RAC-C
Ostomy Wound Management 2008; 54(11):56-58

Acoustic Pressure Wound Therapy to Debride Unstageable Pressure Ulcers in the Acute Care Setting: A Case Series
Sarah Medrano, RN, BNS, WOCN and Mary Jo Beneke, RN, BSN, WOCN
Ostomy Wound Management 2008; 54(12):54-58

Extended Care Professional Nursing (ECPN) - Case Series

Source: www.extendedcarenews.com

MIST Therapy® Thoughts on Therapy Cases Series #1
Kristin Thurman. PT, CWS
ECPN 2007; 115:39-43

MIST Therapy® Thoughts on Therapy Cases Series #2
Jaime Haan, PT, CWS; Sharon Lucich, PT, CWS
ECPN 2007; 116:39-43

MIST Therapy® Thoughts on Therapy Cases Series #3
Pamela Cole, MSPT, CWS
ECPN 2007; 117:39-43

MIST Therapy® Thoughts on Therapy Cases Series #4
Chris Fleming, RN, WCC
ECPN 2007; 118:36-40

MIST Therapy® Thoughts on Therapy Cases Series #5.
Denise Demps Knight, PT, Glenda Diaz, RN and Tere Sigler, PT, CWS
ECPN 2007; 119:36-40

MIST Therapy® Thoughts on Therapy Cases Series #6
Debra Rodgers-Olson, PT, CWS; Nirupama Jacob, PT, CWS; Starley Bartholomew, PT, CWS; Janelle Luther, PT; Angel Snyder, PT, CWS and Christine Copeland. PT
ECPN 2007; 120:36-41

MIST Therapy® Thoughts on Therapy Cases Series #7
Marcy A. Turkos, PT, DPT, CWS
ECPN 2007; 122:36-40

MIST Therapy® Thoughts on Therapy Cases Series #8
Debra Caswell, RN, NP-C
ECPN 2007; 123:36-44

MIST Therapy® Thoughts on Therapy Cases Series #9
Molly Anderson, PT and Angela Drew, PT
ECPN 2007;124:36-42

Animal Studies

Effects of Ultrasound Delivered through a Mist of Saline to Wounds in Mice with Diabetes Mellitus
H.A. Thawer, BScPT, MSc, PhD and P.E. Houghton, BScPT, PhD
J Wound Care 2004; 13(5):1–6
Source: Click here to view abstract on PubMed

Physiological Effect of Ultrasound Mist on Fibroblasts
Jengyu Lai, DPM and Mark R. Pittelkow, MD
Int J Dermatol 2007; 46(6):587-593
Source: Click here to view abstract on PubMed

Other Articles

The Sound of Healing. Ultrasound is Picking Up Popularity for Healing Chronic Wounds
Jeffrey Lasko, MPT, C; Joseph Kochik, PTA and Thomas Serena, MD, FACS
Advances for PT 2009; 20(14):20-22
Source: www.physical-therapy.advanceweb.com

Saving Limbs by Healing Chronic Diabetic Foot and Leg Wounds
Dennis McGrath
Diabetes Health Online Journal 8/20/09
Source: www.diabeteshealth.com

Getting MISTY Over Wound Care
Dea J. Kent, RN, CWOCN, NP-C, MSN
Diabetes Health Online Journal 8/20/09
Source: www.nursing2009.com

Posters

Efficacy of Combined Modality Usage To Treat Chronic Pressure Wounds. Alma Lumabas, PTA, WCC. Forest Ville Extended Care, Niles, IL. 2009.

Planned Surgical Interventions Avoided in Necrotizing Fascitis and MRSA Wounds: A Case Series Using Noncontact Low-Frequency Ultrasound. Julie Ho, RN, MA, CWCN, Kindred Hospital, Scottsdale, Arizona, 2009.

Preparing and Avoiding Graft Procedures in Necrotic or Infected Wounds Using Noncontact Low-Frequency Ultrasound*: A Case Series. Coleen Ferrin, LPN, WCC; Barbara L. Hollis, LPN; Michele L. Jones,LPN; Kenneth O. Anaeme MD, FAAP, WCC, FACCWS, ABPM/UHM. Trillium Specialty Hospital, Mesa, Arizona. ASWC 2009.

Cost Effectiveness of Noncontact Low-Frequency Ultrasound* Therapy for Nonhealing Wounds in a Long-Term Acute-Care Hospital: A Case Series. Kenneth O. Anaeme MD, FAAP, WCC, FACCWS, ABPM/UHM; Coleen Ferrin, LPN, WCC; Barbara L. Hollis, LPN; Michele L. Jones, LPN. Trillium Specialty Hospital, Mesa, Arizona. ASWC 2009.

Noncontact Low-Frequency Ultrasound* Stimulates Healing of Recalcitrant Venous Leg Ulcers: A Case Series. David Eisenbud, MD, CWS, FACS, Overlook Hospital Wound Healing Program, Summit, New Jersey. ASWC 2009.

Noncontact Low-Frequency Ultrasound* for Treatment of Wounds with Suspected Cellulitis Infection: A Case Series. Shari L. Scheider, PT, DPT, Banner Gateway Medical Center, Gilbert, Arizona. ASWC 2009.

Noncontact Low-Frequency Ultrasound* in Conjunction with High-Voltage Electrical Stimulation** for Complete Wound Healing in Complex, Chronic, Lower-Extremity Wounds: A Case Series. Jeffrey Lasko, MPT, Joe Kochik, PTA, Matthew Sabo, DPM, FACFAS, Thomas Serena, MD, FACS Armstrong County Memorial Hospital, Snyder Institute for Vascular Health and Research, Kittanning, Pennsylvania. 2009.

Noncontact Ultrasound in the Management of Pyoderma Gangrenosum S. Garcia-Lavin DPM, M. Fabbi MD, B. Lin DPM, G. Habershaw DPM, FACFAS; V. Driver MS, DPM, FACFAS Limb Preservation Research Team, Department of Surgery, Boston University School of Medicine. DLS, 2009.

A Retrospective Analysis of the Efficacy of Adjuvant Non-Contact Low-Frequency Ultrasound Therapy on Wound Pain. Hakim, Daniel J.2, 1; Myers, Barbara A.1; Cooke, Lydia R.2, 1; Hakim, Ellen W.2. The Integrated Wound Healing Center at Franklin Square Hospital, MedStar Health, Baltimore, MD, USA. 2. Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, USA. DSL 2009.

Healing Chronic Ulcerative Pyoderma Gangrenosum Using Noncontact Low Frequency Ultrasound Therapy: A Case Report: Kessa Mauras DPM1, Matteo Fabbi MD2, Gary Gibbons MD2, Christopher Locke DPM2, Vickie R Driver DPM, MS21 Wyckoff Heights Medical Center, Brooklyn, NY; 2 Boston University School of Medicine, Boston Medical Center, Boston, MA. DLS 2009.

Adjunctive Use of Noncontact Low-Frequency Ultrasound* for Treatment of Suspected Deep Tissue Injury: A Case Series. Jeremy Honaker, RN, BSN, CWOCN, Michael Forston, PT, Central Baptist Hospital, Lexington, Kentucky. SAWC Fall 2009.

Adjunctive Use of Acoustic Pressure Wound Therapy to Heal an Infected Left Ventricular Assist Device (LVAD) Driveline Exit Site. ICCAC 2009, Kurien

Acoustic Pressure Wound Therapy* for Debridement of Infected, Nonhealing Wounds: A Case Series. Marilyn K. Boyle, BSN, RN, CWOCN. Select Specialty Hospital - Pontiac, Pontiac, Michigan. WOCN 2009

Acoustic Pressure Wound Therapy* for Treatment of Chronic Wounds in Medically Complex Patients in a Home Health Setting, Mia Pacheco, RN, CWCN and Patricia Larson, MD; Care for Life Home Health, Elgin, IL. SAWC 2009

The Role of Ultrasonic Debridement in a Physician-Run Wound Care Program, Dana Altman, RN; Shawn Christenson, RN, BSN; Sue Kennel, RN, BSN, CWCN; Judy Madura, RD, RN, CWOCN; Pat Gill, RN, MSN, CWON; Armando Ortega, MA; Griselda Aguirre, MA Banner Good Samaritan Outpatient Wound Care Program, Phoenix, Arizona. SAWC 2009.

Adjunctive Use of Acoustic Pressure Wound Therapy* for Closure of Chronic Wounds in Diabetic Patients, Jennifer Eingle, PT, DPT Kindred Healthcare, Regency Place of Castleton, Indianapolis, Indiana. SAWC 2009

Rapid Debridement of Unstageable Pressure Ulcers Using Acoustic Pressure Wound Therapy*: A Case Series, Sarah Medrano, RN, BSN, WOCN, and Mary Jo Beneke, RN,BS, CWOCN. Yuma Regional Medical Center, Yuma, Arizona. SAWC 2009

Acoustic Pressure Wound Therapy* for Complete Wound Healing in Complex, Chronic, Lower-Extremity Wounds: A Case Series, Jeffrey Lasko, MPT, Joe Kochik, PTA, and Thomas Serena, MD, FACS. Armstrong County Memorial Hospital (Snyder Institute for Vascular Health and Research), Kittanning, Pennsylvania. SAWC 2009

Acoustic Pressure Wound Therapy* to Prepare Wound Beds for Graft or Flap Closure Procedures: A Case Series, Cory Scott, LPN, Gila River Indian Care Center, Laveen, Arizona. SAWC 2009

Combination of High-Voltage Electrical Stimulation* and Acoustic Pressure Wound Therapy** for Treatment of Pressure Ulcers: A Case Series, Jody Wong, PT, CWS, CLT, Stewart Rehabilitation Center Outpatient Clinic, Ogden, Utah. SAWC 2009

Debridement of Pressure Ulcers Using Acoustic Pressure Wound Therapy* in the Absence of Sharp Debridement in a Skilled Nursing Facility, Ernestine Crank, LPN, Payson Care Center, Payson, Arizona. SAWC 2009

Closure of a 14-Year Chronic Diabetic Foot Ulcer with the Adjunctive Use of Acoustic Pressure Wound Therapy*. Jennifer Eingle, PT, DPT Kindred Healthcare, Regency Place of Castleton, Indianapolis, Indiana

A Case Report of Noncontact, Low-Frequency Ultrasound Therapy* for Debridement of a Sensitive Perineal Wound. Donna Radochonski, PT, and Kristen Ragan, PT, DPT,Evergreen Healthcare Center, Evergreen, Illinois

In Vivo-In Vitro Evaluation of Bacteria Aerosolization During Treatment with Acoustic Pressure Wound Therapy* for Infected Wounds. Kan Lam, Mike Peterson, Dinorah Ochoa, Ann Wang, Sisy Shi and Paul Attar, BRIDGE PTS (Preclinical Testing Services), San Antonio, Texas, Celleration Inc., Eden Prairie, Minnesota

Acoustic Pressure Wound Therapy* in Four Patients with Venous Stasis or Pressure Ulcers. Candace Grande, LPN, East Mesa Healthcare Center, Mesa, Arizona

Acoustic Pressure Wound Therapy* for Treatment of a Painful, Infected Eczema Rash in a Pediatric Patient. Christine Tompkins, MSPT, CWS, Banner Health, Gilbert, Arizona

Acoustic Pressure Wound Therapy* for Treatment of Infected Wounds of the Groin and Perineum/Scrotum. Lindsey Wagner, PT, and Barbara Zomick, PTA, CWS, Advocate Christ Hospital, Oak Lawn, Illinois

Preparing the Wound Bed for Apligraf: Use of Acoustic Pressure Wound Therapy* in Two Patients with Large Venous Ulcers. Heather Rooney, PT, Lutheran General Hospital Wound Care Center, Park Ridge, Illinois

Combined Use of Negative Pressure Wound Therapy and Acoustic Pressure Wound Therapy* to Prepare Infected, Open Postsurgery Wounds for Secondary Surgical Closure. Specialty Hospital of Washington Capitol Hill, Washington, DC. Melania Howell-Taylor, RN, BSN, CWOCN, DAPWCA; Macy G. Hall Jr., MD, FACS; William J. Brownlee III, MD; Mary Taylor, C-NP

Treatment of Chronic, Infected Pressure Ulcers with Noncontact, Low-Frequency Ultrasound Therapy. Ernestine Crank, LPN, Payson Care Center, Payson, Arizona, 2008

Acoustic Pressure Wound Therapy* for Mixed Partial- and Full-Thickness Burns in a Rural Wound Center. John H. Samies, MD, and Marie Gehling, RN, BSN, CWOCN, The Regional Medical Center of Orangeburg, Orangeburg, South Carolina, 2008

Noncontact, low-frequency ultrasound therapy for debridment and closing of tunnels in infected chronic wounds. Buth L., Sacks P., Martinez R.

Noncontact, low-frequency, therapeutic ultrasound* painlessly accelerated healing in venous stasis ulcers: a case series study. Christopher Paul Fleming, RN, WCC Monticello-Big Lake Hospital Wound Care Center, Monticello, MN, 2008

Clinical Benefit of Noncontact, Low-Frequency Ultrasound therapy* for Chronic Wound Treatment in a Long-Term, Acute Care Setting. Jane Nguyen, PT, DPT; Lori Thomas, PTA; and Lisa Cotterall, PT, DPT, CWS St. Agnes Continuing Care Center, 2008

Limb Salvage Using Low-Intensity, Low-Frequency, Noncontact Ultrasound* in a Patient with Osteomyelitis and Clinically Low Capability of Healing. Tracy Mose, PT, CWS, Prairie Manor Nursing and Rehabilitation Center, Chicago Heights, Illinois, 2008

Low-frequency, Therapeutic Ultrasound* Treatment Resolved Necrosis and Undermining in Nonhealing Trauma Wounds. Andreson M., Drew A.

Low-frequency, therapeutic ultrasound. Accelerated healing and prevents amputation in severe, chronic wounds. Scott

Rapid Resolution of a Segmental Infantile Hemangioma Using Non-thermal Low-frequency Ultrasound: A Novel Therapeutic Intervention. Thomas Serena, MD, FACS Penn North Centers for Advanced Wound Care and NewBridge Medical Research, Warren, Pennsylvania, 2008

Complex And Chronic Wounds Resolved With Noncontact, Low-frequency, Therapeutic Ultrasound* Therapy. Denise Demps Knight, PT, Glenda Diaz, RN, and Tere Sigler, PT, CWS Archbold Center for Wound Management, Thomasville, GA, 2008

Treatment of Burn Patients Using Non-contact, Low-Frequency Ultrasound Therapy. Kristin Waldrop PT, DPT & Ann Serfass PTA, CWS St. Joseph Medical Center, 2008

Utilizing Low-Frequency, Noncontact Ultrasound in the Management of Chronic Wounds. Marcy A. Turkos, DPT, CWS, Karalyn Stoner, DPT, Jennifer A. Gardner, DPT, CWS Mercy Rehab Associates St. Agnes Continuing Care Center

Effectiveness of Low-Frequency, Noncontact Ultrasound for Closure of a Chronic Wound. D. Michelle Connor, RN, Salem Village Nursing and Rehabilitation Center, Joliet, Illinois

Noncontact, Low-Frequency Ultrasound Therapy for Infected Pressure Ulcers in a Patient with Multiple Comorbidities. Ann Bingham, RN, BSN, CWOCN, Oak Tree Hospital at Baptist Regional Medical Center, Corbin, Kentucky

Healing of Surgical and Burn Wounds with Noncontact, Low-Frequency Ultrasound Therapy. Sue Champion, RN, BSN, CWOCN, West Shore Hospital, Manistee, Michigan

Use of Noncontact, Low-Frequency Ultrasound to Aid the Healing of a Trauma Wound in a Prednisone-Dependent Patient. Bobbi Eads, RN, CWON, Community Hospital Anderson, Anderson, Indiana

Noncontact, Low-Frequency Ultrasound Therapy to Expedite Healing of a Dehisced Surgical Incision. Cathy Blackwell, RNC, CWOCN, St. Vincent Seton Specialty Hospital, Indianapolis, Indiana

Low-frequency therapuetic ultrasound rapidly healed challenging wounds. Cole

Case Studies Demonstrate Effectiveness of Noncontact, Low-Frequency Therapeutic Ultrasound in Complicated Wounds. Haan, Lucich

Low-frequency ultrasound therapy evaluated in patients with nonhealing wounds and vascular insufficiency. Caswell, Wander, Yaple, Hoffman, Calilan, Cortez

Results of a non-invasive protocol for healing leg ulcerations in sickle cell anemia utilizing non-contact ultrasound and bilayered living cell therapy SAWC 2007. Dr. Samies

Effectiveness of noncontact, low-intensity, low-frequency therapuetic ultrasound in wound treatment: a case series study. Thurman, K

Hidradenitis Suppurativa: Another Treatment Option. Poster Presentation ASWC 2005. Knight, Sigler, Loehne

Limb salvage in bilateral ischemic leg ulcers with exposed tendons with ultrasound and bilayered cell therapy. Poster Presentation SAWC 2006. Dr. Samies

MIST Assisted Healing in Wound Bed Preparation for Bioengineered Tissue. Dr. Ennis

Noncontact, Low-frequency, Therapeutic Ultrasound for Four Cases of Complicated or Difficult-to-Manage Wounds. Poster Presentation APT 2007. Haan, Lucich

A novel approach to management of complicated wounds with exposed tendon, bone and joint utilizing ultrasound. Dr. Samies

The use of ultrasonic therapy in a painful burn wound. Poster Presentation SAWC 2006. Dr. Serena

Treatment of web space ulcerations with non-contact low frequency ultrasound. Poster Presentation SAWC 2006. Dr. Kavros